AVANAFIL&DAPOXETINE AVANDRO TABLET Avanafil and Dapoxetine Combination Formula

Product Name: AVANDRO

Manufacturer: THE LOTUS BIOTECH

Dosage Form & Strength: Each tablet contains 100 mg Avanafil and 60 mg Dapoxetine; 10 tablets per box.

Target Population: Adult males (aged 18 and above); contraindicated in women and minors.

I. Drug Composition and Mechanism of Action

Avanafil (100 mg): A PDE5 inhibitor that rapidly increases blood flow to the penile corpus cavernosum, facilitating an erection; onset of action can occur as early as 15 minutes after administration.

Dapoxetine (60 mg): A selective serotonin reuptake inhibitor (SSRI) that increases serotonin levels in the brain, thereby prolonging the ejaculatory latency period and improving symptoms of premature ejaculation.

Dual Efficacy: Simultaneously addresses both Erectile Dysfunction (ED) and Premature Ejaculation (PE).

II. Indications

Used for the treatment of erectile dysfunction in adult males and for the improvement of symptoms associated with premature ejaculation.

III. Dosage and Administration

1. Timing: Take orally 30–60 minutes prior to sexual activity. Swallow the tablet whole with warm water; do not chew or break the tablet.

2. Recommended Dosage: One tablet per dose (100 mg + 60 mg); do not exceed one dose within a 24-hour period.

3. Food Interaction: May be taken with or without food; however, avoid high-fat meals, as they may delay the onset of action.

4. Conditions for Efficacy: Sexual stimulation is required for the medication to take effect; an erection will not occur in the absence of stimulation.

IV. Contraindications (Absolute Prohibitions)

Patients with known hypersensitivity (allergy) to Avanafil, Dapoxetine, or any of the excipients.

Patients currently taking nitrate medications (e.g., nitroglycerin, isosorbide mononitrate); concomitant use may lead to severe hypotension or shock.

Patients with severe hepatic or renal impairment, uncontrolled hypotension or hypertension, a history of recent myocardial infarction (heart attack) or stroke, or existing cardiac disease.

Patients with penile deformities, sickle cell anemia, or other conditions that predispose them to priapism (prolonged erection).

V. Precautions

1. Medication Safety: This is a prescription-only medication; it should be used only after a medical evaluation by a physician and must not be purchased or used indiscriminately without medical supervision. 2. Adverse Effect Monitoring: Common side effects include headache, dizziness, facial flushing, nausea, and indigestion; these are mostly mild to moderate and transient. If discomfort persists, discontinue use and seek medical attention.

3. Special Populations:

Patients with mild hepatic or renal impairment should use with caution and require a dosage reduction; use is contraindicated in patients with moderate to severe impairment. 

Patients with a history of epilepsy, psychiatric disorders, or bleeding tendencies should use with caution.

4. Drug Interactions:

Concomitant use with nitrates, riociguat, or alpha-blockers is strictly prohibited. 

When used concomitantly with CYP3A4 inhibitors (such as ketoconazole, erythromycin, or HIV protease inhibitors), a significant dosage reduction and close monitoring are required.

5. Alcohol Consumption and Driving: Avoid consuming alcohol after taking the medication, as it may exacerbate dizziness and hypotension; do not drive or operate heavy machinery.

6. Priapism: If an erection persists for more than 4 hours, seek immediate medical attention; failure to do so may result in permanent penile tissue damage.

VI. Adverse Reactions

Common: Headache, dizziness, facial flushing, nasal congestion, nausea, diarrhea, insomnia.

Uncommon: Palpitations, blood pressure fluctuations, visual disturbances, muscle pain, rash.

Rare: Priapism, severe allergic reactions, seizures, abnormal liver function.

VII. Drug Interactions

1. Strictly Prohibited Combinations: Nitrates, riociguat, and certain alpha-blockers.

2. Combinations Requiring Caution:

Potent CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin, HIV protease inhibitors): Significantly increase plasma concentrations of avanafil; dosage reduction is required. 

Concomitant use with dapoxetine, SSRIs, SNRIs, MAOIs, or tramadol increases the risk of serotonin syndrome.

3. Other: Concomitant use with antihypertensive medications may potentiate their blood pressure-lowering effects; blood pressure monitoring is required.

VIII. Use in Special Populations

Pregnant/Lactating Women: Contraindicated.

Children/Adolescents: Contraindicated in patients under 18 years of age.

Elderly Patients: Use with caution in patients over 65 years of age; the initial dosage should be halved, and blood pressure and adverse effects should be monitored. Hepatic and Renal Insufficiency:

Mild: Use with caution; dosage reduction is recommended. 

Moderate to Severe: Contraindicated (do not use).

IX. Storage and Packaging

Storage: Keep tightly sealed in a cool, dry place; protect from light; store at a temperature of 15–30°C.

Packaging: Aluminum-plastic blister pack; 10 tablets per box.

X. Important Notice

This medication is an Indian generic combination drug that has not received market approval from China's NMPA. Purchasing or using this product within China carries inherent legal and safety risks.

For issues regarding erectile dysfunction or premature ejaculation, it is strongly recommended to seek medical attention first. Pursue standardized treatment only after a definitive diagnosis of the underlying cause has been established; do not use such medications blindly.

Prior to use, you must fully disclose your complete medical history and current medications to your physician to avoid potentially severe drug interactions.

Guidelines for Purchasing Sexual Health Products:

Note: Oral medications designed to aid erections in men function only in the presence of sexual stimulation; they do not automatically induce an erection.

When using medications containing active ingredients such as Sildenafil, Vardenafil, Tadalafil, Avanafil, or Priligy, many users are concerned about the possibility of failing to achieve the desired results.

Based on a combination of clinical data and real-world user feedback, the proportion of individuals for whom a specific drug is ineffective varies slightly among different medications:

Sildenafil: Approximately 15–20% of users do not achieve the expected results after administration.

Vardenafil: The proportion of non-responders is similar to that of Sildenafil, standing at approximately 15–22%.

Tadalafil: Due to its longer half-life, this medication is suitable for a slightly broader patient population; consequently, its failure rate is slightly lower, at approximately 12–18%.

Avanafil: Characterized by a rapid onset of action and rapid metabolism, the proportion of non-responders is approximately 14–19%.

Priligy: Specifically designed to treat premature ejaculation, the efficacy of this medication is more heavily influenced by individual neurological sensitivity and psychological state; as a result, its failure rate is relatively higher, at approximately 20–25%. It must be clearly understood that for some individuals, a lack of efficacy after use is by no means an indication of a product quality issue; rather, it is the result of the interplay between the drug's mechanism of action and the individual's unique physiological and pathological conditions. Even with original, patented products—such as Pfizer's Viagra (sildenafil)—a significant proportion of users may experience no effect. For instance, approximately 20% of men do not respond to Viagra, a phenomenon unrelated to product quality. With many male enhancement products, it is common to encounter situations where the exact same box of medication works for one person but not another; conversely, switching to a different product might prove effective for the second person while failing to work for the first. This store guarantees that all sexual health products sold are 100% authentic; however, we cannot guarantee that 100% of users will achieve their desired results. Please ensure you have carefully considered these factors before placing an order.

The specific reasons for varying efficacy differ depending on the medication:

Sildenafil / Vardenafil / Avanafil: All three function by promoting vasodilation. Their efficacy is influenced by individual metabolic capacity (specifically, how liver and kidney function affect the rate at which the drug is broken down), underlying medical conditions (such as diabetes or hypertension, which can damage blood vessels and reduce drug efficiency), and usage context (e.g., consuming alcohol concurrently can inhibit the drug's effects, while a high-fat meal may delay the absorption of sildenafil and vardenafil). If severe arterial vascular disease is present, the medication may struggle to facilitate blood flow, and its efficacy will naturally be limited.

Tadalafil: Although its mechanism of action is similar to the three drugs mentioned above, it remains in the body for a longer duration. Nevertheless, its efficacy is still influenced by factors such as individual sensitivity to the drug, and the presence of severe prostate conditions or spinal cord injuries. For some individuals with weaker receptor binding capabilities, the results may be less than ideal.

Priligy: This medication improves ejaculatory control by inhibiting neurotransmitter reuptake. Its efficacy is closely correlated with the individual's neural conduction efficiency, psychological state (anxiety or stress can counteract the drug's effects), and whether the dosage is appropriately matched to the user's body weight and the severity of their condition. If there is abnormal neural sensitivity or a history of long-term psychogenic premature ejaculation, the drug's regulatory effect may be diminished.

If you have used any of the aforementioned medications—or combination tablets—and the results did not meet your expectations, you must strictly avoid self-medicating by increasing the dosage, switching medications, or continuing to take the drug blindly over the long term. We strongly recommend consulting a urologist or a specialist in men's health as soon as possible. A physician will assess your physical condition through a detailed medical consultation. By integrating examination results, they will adjust your medication regimen—such as optimizing dosages or switching medication types—or combine it with psychological interventions and behavioral training to formulate a treatment plan that is best suited to your specific needs.

Product Specifications

Product Name: Golden Submariner Avanafil & Dapoxetine Dual-Effect Tablets (10 Tablets/Box) — AVANAFIL & DAPOXETINE AVANDRO TABLET — "Peak Yellow Beauty" Edition

Common Name: Golden Submariner Avanafil & Dapoxetine Dual-Effect Tablets

Ingredients: Each tablet contains 100 mg of Avanafil and 60 mg of Dapoxetine.

Dosage Form: Tablets

Specification: 10 tablets per box

Manufacturer: THE LOTUS BIOTECH

Indications: Used for the treatment of erectile dysfunction in adult males, and for the improvement of symptoms associated with premature ejaculation.

Usage and Dosage:

1.  Timing: Take orally 30–60 minutes prior to sexual activity. Swallow the tablet whole with warm water; do not chew or break the tablet.

2.  Recommended Dosage: 1 tablet per dose (100 mg + 60 mg); do not exceed one dose within a 24-hour period.

3.  Dietary Considerations: May be taken on an empty stomach or with a meal; avoid consuming high-fat meals, as this may delay the onset of action.

4.  Conditions for Efficacy: Sexual stimulation is required for the medication to take effect; an erection will not occur in the absence of stimulation.