VILITRA 40 Vardenafil Tablets 40mg

Generic Name: Vardenafil Hydrochloride Tablets

Brand Name: Vilitra 40

Manufacturer: Centurion Laboratories

Specifications: 40mg/tablet; 100 tablets/box

I. Main Ingredients

Each tablet contains 40mg of vardenafil hydrochloride. Excipients: lactose, microcrystalline cellulose, magnesium stearate, and film-coating materials.

Pharmacological Classification: Selective phosphodiesterase type 5 (PDE5) inhibitor.

II. Indications

For adult males aged 18 and older only; indicated for erectile dysfunction (ED)—the inability to achieve or maintain a penile erection of sufficient rigidity for sexual intercourse. Sexual stimulation is required for the drug to take effect; it does not enhance libido. Contraindicated for women and children.

III. Pharmacological Action

Upon sexual stimulation, nitric oxide is released in the corpus cavernosum, activating guanylate cyclase to increase cGMP levels. Vardenafil inhibits PDE5, thereby reducing cGMP breakdown; this leads to the relaxation of smooth muscle in the corpus cavernosum and increased blood flow, resulting in an erection. The drug is ineffective without sexual stimulation.

IV. Dosage and Administration

1. Standard Administration

1. Take orally with warm water 30–60 minutes before sexual activity. Onset is faster on an empty stomach; high-fat meals may delay absorption and onset time. Can be taken with or without food.

2. Maximum of one tablet (40mg) per 24 hours; strictly avoid taking multiple doses or stacking doses within a single day. The drug's effect lasts 5–8 hours; multiple sexual encounters are possible within 8 hours of administration (provided sexual stimulation is maintained).

> Important Reminder: The maximum safe single dose approved domestically for the originator drug is 20mg. A 40mg dose exceeds the dosage recommended for the originator drug and should only be used for severe ED under medical supervision. First-time users are advised not to start directly with 40mg but to begin with a lower dose, such as 10mg or 20mg. 2. Dosage reduction for special populations

1. Elderly (≥65 years old): Preferred starting dose is 10–20 mg; the standard 40 mg dose is contraindicated.

2. Mild-to-moderate hepatic impairment or moderate-to-severe renal impairment: 40 mg dose is contraindicated; maximum dose is 20 mg.

3. Patients taking alpha-blockers (antihypertensives or medications for prostate conditions): Starting dose ≤5–10 mg; 40 mg dose is not permitted.

4. Concomitant use of CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, erythromycin): 40 mg dose is strictly prohibited; use the lowest possible dose.

V. Contraindications (Must not be taken)

1. Patients taking nitrates (e.g., nitroglycerin, isosorbide mononitrate, isosorbide dinitrate): Concomitant use may cause fatal hypotension; this drug should only be used 7 days after discontinuing nitrates.

2. Patients allergic to vardenafil or any excipients in this product.

3. Severe heart disease, unstable angina, history of myocardial infarction or stroke within the past 6 months, refractory hypotension (resting blood pressure <90/60 mmHg), or refractory hypertension.

4. Retinitis pigmentosa, hereditary retinal disorders, or severe hepatic/renal failure.

5. Minors under 18 years of age; pregnant or breastfeeding women.

VI. Precautions & Prohibited Combinations

1. Do not take concomitantly with other PDE5 inhibitors used for erectile dysfunction, such as sildenafil or tadalafil.

2. Do not consume grapefruit or grapefruit juice: They inhibit drug metabolism, causing a sharp rise in plasma drug concentration and significantly worsening side effects.

3. Heavy alcohol consumption: Alcohol dilates blood vessels, exacerbating hypotension and reducing drug efficacy; limit alcohol intake before and after taking the medication.

4. Concomitant use with antihypertensives (e.g., nifedipine, valsartan, alpha-blockers) increases the risk of hypotension; dosage adjustment by a physician is required. VII. Adverse Reactions

1. Common (mild, transient; resolves spontaneously within 1–4 hours)

Headache, facial flushing, nasal congestion/runny nose, indigestion, acid reflux, dizziness, lower back pain, mild yellow-tinted vision or blurred vision.

2. Uncommon adverse reactions

Tachycardia, palpitations, conjunctival congestion, drowsiness.

3. Serious medical emergencies (discontinue use immediately and seek medical attention)

1. Priapism (prolonged erection >4 hours): Risk of ischemic necrosis of the corpus cavernosum; requires emergency treatment.

2. Sudden unilateral or bilateral hearing loss, tinnitus; sudden, severe vision loss or visual field defects.

3. Chest tightness or pain, severe dizziness or fainting, difficulty breathing, generalized skin rash, laryngeal edema.

VIII. Management of Overdose

Single dose >40 mg: Significant myalgia, back pain, severe headache, hypotension, visual abnormalities. No specific antidote exists; manage symptomatically with fluid replacement and monitoring. Dialysis cannot remove vardenafil (due to high plasma protein binding); seek immediate medical attention.

IX. Storage Conditions

Keep tightly sealed; store in a cool, dry place below 25°C, protected from light. Keep out of reach of children and away from moisture and high temperatures.

X. Important Safety Warnings

1. Individuals with underlying chronic conditions (hypertension, hyperlipidemia, hyperglycemia, heart disease, or liver/kidney issues) must strictly avoid self-administering the high 40 mg dose.

2. If chest pain occurs after taking the medication, do not self-administer sublingual nitroglycerin; call emergency services immediately.

3. Individuals who work at heights, operate machinery, or drive should avoid operating dangerous equipment if dizziness occurs after taking the medication.

Information on Purchasing Sexual Health Products:

Note: Oral erection-enhancing medications for men require sexual stimulation to be effective; they do not induce erections automatically.

When using medications containing sildenafil, vardenafil, tadalafil, avanafil, or dapoxetine (Priligy), many users are concerned about whether the expected results will be achieved. Based on a combination of clinical data and real-world user feedback, the proportion of individuals for whom different medications prove ineffective varies slightly:

Sildenafil: Approximately 15%–20% of users do not achieve the expected results after administration.

Vardenafil: The proportion of non-responders is similar to that of Sildenafil, standing at approximately 15%–22%.

Tadalafil: Due to its longer half-life, this medication is suitable for a slightly broader range of patients; consequently, its failure rate is slightly lower, at approximately 12%–18%.

Avanafil: Characterized by a rapid onset of action and rapid metabolism, the proportion of non-responders is approximately 14%–19%.

Priligy: Specifically designed to treat premature ejaculation, this medication is more heavily influenced by individual neurological sensitivity and psychological state; as a result, its failure rate is relatively higher, at approximately 20%–25%.

It is crucial to clarify that for some individuals, a lack of efficacy is by no means an indication of a product quality issue; rather, it is the result of the interplay between the drug's mechanism of action and the individual's unique physiological and pathological conditions. Even the original brand-name products—such as Pfizer's Viagra (Sildenafil)—are known to be ineffective for a significant proportion of users (approximately 20% of men experience no effect), and this is not attributed to product quality defects. With many male enhancement products, it is common to encounter scenarios where—even with the exact same box of medication—it proves effective for one person but ineffective for another; conversely, switching to a different product may yield results for the second person while proving ineffective for the first. This store guarantees that all sexual health products sold here are 100% authentic; however, we cannot guarantee that 100% of users will achieve their desired results. We strongly urge you to carefully consider these factors before placing an order. The specific reasons vary depending on the medication:

Sildenafil / Vardenafil / Avanafil: These three drugs work by promoting vasodilation. Their efficacy is influenced by individual metabolic capacity (liver and kidney function affecting the rate of drug breakdown), underlying medical conditions (such as diabetes or hypertension, which damage blood vessels and reduce drug efficiency), and the circumstances of use (alcohol consumption can inhibit the drug's effect, while high-fat meals may delay the absorption of sildenafil and vardenafil). Additionally, in cases of severe arterial disease, the drugs struggle to facilitate blood flow, naturally limiting their effectiveness.

Tadalafil: Although its mechanism of action is similar to the three drugs mentioned above, it remains in the body for a longer period. However, its efficacy is still influenced by factors such as individual drug sensitivity and the presence of severe prostate disease or spinal cord injuries; some individuals may experience suboptimal results due to weaker receptor binding affinity.

Priligy (Dapoxetine): This drug improves ejaculation control by inhibiting neurotransmitter reuptake. Its effectiveness is closely linked to individual nerve conduction efficiency, psychological state (anxiety and tension can counteract the drug's effects), and the appropriateness of the dosage relative to body weight and the severity of the condition. If there is abnormal nerve sensitivity or long-standing psychogenic premature ejaculation, the drug's regulatory effect may be limited.

If the results of using any of the aforementioned medications or dual-effect tablets fall short of expectations, do not arbitrarily increase the dosage, switch medications, or continue taking them blindly over the long term; instead, consult a urologist or andrologist promptly. A doctor will assess your physical condition through a detailed consultation and, based on test results, adjust your treatment plan (e.g., optimizing dosage or changing the type of medication) or incorporate psychological interventions and behavioral training to develop a solution better suited to your needs. Specifications

Product Name: Vardenafil Hydrochloride Tablets (Levitra) 40mg x 100 tablets/box (VILITRA 40)

Common Name: Vardenafil Hydrochloride Tablets

Active Ingredient: Vardenafil hydrochloride

Dosage Form: Tablets

Specifications: 40mg/tablet; 100 tablets/box

Manufacturer: Centurion Laboratories

Indications: For adult males (18+) with erectile dysfunction (ED)—defined as the inability to achieve or maintain a penile erection of sufficient rigidity for sexual intercourse. Sexual stimulation is required for the drug to take effect; it does not increase libido. Contraindicated for women and children.

Usage and Dosage:

1. Standard Administration

- Take orally with warm water 30–60 minutes before sexual activity. It acts faster on an empty stomach; high-fat meals may delay absorption and onset of action. Can be taken with or without food.

- Maximum of one tablet (40mg) per 24 hours; strictly avoid taking multiple doses or stacking doses within a single day. The effect lasts 5–8 hours; multiple sexual encounters are possible within 8 hours of ingestion (provided there is continued sexual stimulation).

> Important Note: The maximum safe single dose approved domestically for the originator drug is 20mg. A 40mg dose exceeds the originator's recommended dosage and should only be used for severe ED under medical supervision. First-time users are advised not to start directly with 40mg; it is recommended to begin with a lower dose of 10mg or 20mg.