Valif Oral Jelly 20mg vardenafil oral

[Drug Name]

Generic Name: Vardenafil Oral Jelly (Valif Oral Jelly)

Brand Name: Apcalis Oral Jelly 20mg

Dosage Form: Oral Jelly

Specification: 20mg Vardenafil per sachet; 7 sachets per box

Manufacturer: Ajanta Pharma Ltd

[Ingredients]

Active Ingredient: Vardenafil 20mg

Excipients: Water, glycerin, gelatin, food flavoring, sweeteners, etc.

[Indications]

For the treatment of erectile dysfunction (ED/impotence) in men.

[Dosage and Administration]

Recommended Dose: Take 1 sachet (20mg) as needed, approximately 25 minutes to 1 hour before sexual activity.

Maximum Dose: Maximum once daily; do not exceed 20mg per day.

Administration: Tear open the sachet and squeeze the gel directly into the mouth to swallow. Can be taken with or without food (avoid taking immediately after a heavy, fatty meal).

Onset of Action: Approximately 25–60 minutes (varies by individual).

Duration of Effect: Typically 4–5 hours (up to 8 hours for some individuals); sexual stimulation is required to maintain the effect.

Precautions:

Sexual stimulation is required for the drug to work; it does not automatically induce an erection.

Do not use concomitantly with nitrates (e.g., nitroglycerin, isosorbide mononitrate), as this may cause potentially fatal hypotension. [Contraindications (Strictly Prohibited)]

Vardenafil is strictly prohibited in the following cases:

Current use or use within the past 24 hours of nitrates (e.g., nitroglycerin, isosorbide mononitrate, pentaerythritol tetranitrate, etc.)—may cause fatal hypotension;

Allergy to vardenafil or any excipients;

Severe cardiovascular disease:

Myocardial infarction, stroke, or unstable angina within the last 6 months;

Severe arrhythmia or NYHA Class III–IV heart failure;

Hypotension (systolic blood pressure <90 mmHg) or uncontrolled hypertension (systolic blood pressure >170 mmHg);

History of non-arteritic anterior ischemic optic neuropathy (NAION);

Hereditary retinal disorders (e.g., retinitis pigmentosa);

Anatomical penile deformity (e.g., penile curvature, Peyronie's disease) or conditions predisposing to priapism (e.g., sickle cell anemia, multiple myeloma, leukemia).

[Warnings and Precautions]

For use by adult males only; contraindicated in women and children.

Priapism:

If an erection lasts longer than 4 hours, seek medical attention immediately!

Delayed treatment may result in permanent erectile dysfunction.

Sudden hearing loss or vision impairment:

Post-marketing reports exist globally; if tinnitus, sudden hearing loss, visual field defects, or blurred vision occur, discontinue use immediately and seek emergency medical care.

Cardiovascular risk:

Sexual activity carries inherent risks for patients with heart disease; cardiac tolerance should be assessed before taking the medication;

If chest pain, dizziness, or nausea occurs during sexual activity, stop immediately and seek medical attention.

Alcohol effects:

Heavy alcohol consumption (>3 units) may increase the risk of hypotension and dizziness; limiting alcohol intake is recommended.

Driving and operating machinery:

Dizziness or visual abnormalities may occur in a small number of individuals; exercise caution when engaging in high-risk activities after taking the medication.

ED may be an early sign of systemic disease!

Patients presenting with ED for the first time are advised to undergo a comprehensive examination, including blood glucose, blood lipids, hormone levels, and cardiovascular health. 【Adverse Reactions】

Common (≥1%):

Headache (most common)

Facial flushing

Dyspepsia, heartburn

Nasal congestion, rhinitis

Dizziness

Back pain, muscle pain (less common and milder than with tadalafil)

Uncommon (<1%):

Visual abnormalities (photosensitivity, slight changes in color perception)

Palpitations, blood pressure fluctuations

Rash, allergic reactions

Rare but serious:

Sudden hearing loss

NAION (vision loss)

Severe hypotension

Priapism (prolonged erection)

Severe allergic reactions (difficulty breathing, laryngeal edema)

【Drug Interactions】

Nitrates: Concomitant use is strictly prohibited

Alpha-blockers (e.g., tamsulosin): Allow an interval of at least 6 hours

Strong CYP3A4 inhibitors (ketoconazole, ritonavir, clarithromycin): Use prohibited

Riociguat (drug for pulmonary arterial hypertension): Use prohibited

Antihypertensives: Use after monitoring blood pressure to ensure safety

【Use in Special Populations】

Elderly (≥65 years): Clearance is slightly reduced; a starting dose of 5 mg is recommended.

Hepatic impairment:

Moderate (Child-Pugh B): Start at 5 mg, maximum 10 mg;

Severe: Use not recommended.

Renal impairment:

Mild to moderate: No dosage adjustment required;

Severe (CrCl <30 mL/min): Start at 5 mg, maximum 10 mg.

Children/Adolescents: Not applicable.

Pregnant/Lactating women: Not applicable (for use by men only).

【Pharmacological Action】

Phosphodiesterase type 5 (PDE5) inhibitor

Mechanism of action: By inhibiting the PDE5 enzyme in the corpus cavernosum of the penis, it enhances the nitric oxide (NO)-cGMP pathway, promoting smooth muscle relaxation and increased blood flow, thereby facilitating an erection in response to sexual stimulation. 【Pharmacokinetics】

Absorption: Rapidly absorbed after oral administration; Tmax ≈ 30–120 minutes

Bioavailability: Approximately 15% (affected by food)

Protein binding: ≈95%

Metabolism: Primarily via hepatic CYP3A4 enzymes

Half-life: Approximately 4–5 hours

Excretion: Feces (61%), urine (28%)

【Storage Conditions】

Store in a sealed container, protected from light, in a dry place below 30°C

Keep out of reach of children

【Packaging】

Aluminum-plastic composite sachet; approximately 10g per sachet; individually packaged

Important Information Regarding Sexual Health Products:

Note: Oral medications for erectile support in men require sexual stimulation to be effective; they do not induce erections automatically.

When using drugs such as sildenafil, vardenafil, tadalafil, avanafil, or Priligy (dapoxetine), many users are concerned about the possibility of not achieving the expected results.

Based on clinical data and real-world user feedback, there are slight differences in the proportion of non-responders among the various drugs:

Sildenafil: Approximately 15%–20% of users do not achieve the expected results;

Vardenafil: The proportion of non-responders is similar to that of sildenafil, at approximately 15%–22%;

Tadalafil: Due to its longer half-life and broader suitability, the non-response rate is slightly lower, at approximately 12%–18%;

Avanafil: Characterized by rapid onset and metabolism; the non-response rate is approximately 14%–19%;

Priligy (dapoxetine): Indicated for premature ejaculation; efficacy is significantly influenced by individual neurological sensitivity and psychological state, resulting in a relatively higher non-response rate of approximately 20%–25%. It must be clearly understood that for some individuals, a lack of efficacy after use is by no means an indication of a product quality issue; rather, it is the result of the interplay between the drug's mechanism of action and the individual's unique physiological and pathological conditions. Even with original, patented products—such as Pfizer's Viagra (sildenafil)—a significant proportion of users may experience no effect. For instance, approximately 20% of men do not respond to Viagra, a phenomenon unrelated to product quality. With many male enhancement products, it is common to encounter situations where the exact same box of medication works for one person but not another; conversely, switching to a different product might prove effective for the second person while failing to work for the first. This store guarantees that all sexual health products sold are 100% authentic; however, we cannot guarantee that 100% of users will achieve their desired results. Please ensure you have carefully considered these factors before placing an order.

The specific reasons for varying efficacy differ depending on the medication:

Sildenafil / Vardenafil / Avanafil: All three function by promoting vasodilation. Their efficacy is influenced by individual metabolic capacity (specifically, how liver and kidney function affect the rate at which the drug is broken down), underlying medical conditions (such as diabetes or hypertension, which can damage blood vessels and reduce drug efficiency), and usage context (e.g., consuming alcohol concurrently can inhibit the drug's effects, while a high-fat meal may delay the absorption of sildenafil and vardenafil). If severe arterial vascular disease is present, the medication may struggle to facilitate blood flow, and its efficacy will naturally be limited.

Tadalafil: Although its mechanism of action is similar to the three drugs mentioned above, it remains in the body for a longer duration. Nevertheless, its efficacy is still influenced by factors such as individual sensitivity to the drug, and the presence of severe prostate conditions or spinal cord injuries. For some individuals with weaker receptor binding capabilities, the results may be less than ideal.

Priligy: This medication improves ejaculatory control by inhibiting neurotransmitter reuptake. Its efficacy is closely correlated with the individual's neural conduction efficiency, psychological state (anxiety or stress can counteract the drug's effects), and whether the dosage is appropriately matched to the user's body weight and the severity of their condition. If there is abnormal neural sensitivity or a history of long-term psychogenic premature ejaculation, the drug's regulatory effect may be diminished.

If you have used any of the aforementioned medications—or combination tablets—and the results did not meet your expectations, you must strictly avoid self-medicating by increasing the dosage, switching medications, or continuing to take the drug blindly over the long term. We strongly recommend consulting a urologist or a specialist in men's health as soon as possible. A doctor will assess your physical condition through a detailed consultation and adjust your medication regimen based on test results (e.g., optimizing dosage or switching medication types). They may also incorporate psychological interventions or behavioral training to create a treatment plan best suited to your needs.

Specifications

Product Name: Valif Oral Jelly (7 sachets/box)

Common Name: Vardenafil Oral Jelly

Active Ingredient: Vardenafil Hydrochloride

Dosage Form: Oral jelly

Specifications: 7 sachets per box

Manufacturer: Ajanta Pharma Ltd

Indication: Treatment of male erectile dysfunction (ED).

Dosage and Administration: Recommended dose: Take 1 sachet (20mg) as needed, approximately 25 minutes to 1 hour before sexual activity.

Maximum dose: Once daily; do not exceed 20mg per day.

Administration: Tear open the sachet and squeeze the jelly directly into the mouth to swallow. Can be taken on an empty stomach or after a meal (avoid taking immediately after a heavy, fatty meal).

Onset of action: Approximately 25–60 minutes (varies by individual);

Duration of effect: Typically 4–5 hours (up to 8 hours for some individuals); sexual stimulation is required for the effect to be maintained.