Apcalis Oral Jelly 20mg Tadalafil

【Drug Name】

Generic Name: Tadalafil Oral Jelly

Brand Name: Apcalis Oral Jelly 20mg

Dosage Form: Oral Jelly

Specification: 20mg Tadalafil per sachet; 7 sachets per box

Manufacturer: Ajanta Pharma Ltd

【Ingredients】

Active Ingredient: Tadalafil 20mg

Excipients: Water, glycerin, gelatin, food flavoring, sweeteners, etc.

【Indications】

For the treatment of erectile dysfunction (ED/impotence) in men.

【Dosage and Administration】

Recommended Dosage: Take 1 sachet (20mg) as needed, approximately 30 minutes to 1 hour before sexual activity.

Maximum Dosage: Maximum once daily; do not exceed 20mg per day.

Administration: Squeeze directly into the mouth and swallow; no water is required. Can be taken with or without food (high-fat meals may slightly delay the onset of action).

Onset of Action: Usually takes effect within 30–60 minutes.

Duration of Action: Effects can last up to 36 hours (hence it is known as the "weekend pill").

Precautions:

Sexual stimulation is required for the drug to work; it does not automatically induce an erection.

Do not use concomitantly with nitrates (e.g., nitroglycerin, isosorbide mononitrate), as this may cause potentially fatal hypotension. [Contraindications]

Use is strictly prohibited in the following cases:

1. Currently taking any form of nitrate medication (used for angina);

2. Allergy to tadalafil or any excipients;

3. Severe cardiovascular disease (e.g., myocardial infarction, stroke, unstable angina, or heart failure within the past 6 months);

4. Severe blood pressure abnormalities (systolic <90 mmHg or >170 mmHg; diastolic >100 mmHg);

5. Hereditary retinal disorders (e.g., retinitis pigmentosa);

6. History of non-arteritic anterior ischemic optic neuropathy (NAION);

7. Severe hepatic or renal impairment (dosage adjustment requires medical assessment).

[Warnings and Precautions]

1. For use by men only; contraindicated for women and children.

2. Not for recreational use; poses health risks.

3. If an erection lasts longer than 4 hours (priapism), seek immediate medical attention; failure to do so may result in permanent penile damage.

4. May cause sudden hearing loss or tinnitus; discontinue use and seek medical attention if these occur.

5. May cause blurred vision or changes in color perception (difficulty distinguishing blue/green); these effects are usually temporary.

6. Alcohol enhances the blood-pressure-lowering effect and increases the risk of dizziness and hypotension; excessive alcohol consumption should be avoided.

7. Apcalis is an unregulated product; there is no guarantee regarding ingredient purity or the absence of contaminants (e.g., sildenafil, hormones, heavy metals), posing risks of toxicity or ineffectiveness.

[Common Side Effects]

Headache (most common)

Indigestion, heartburn

Back pain, muscle pain

Nasal congestion, facial flushing

Dizziness

Visual abnormalities (e.g., light sensitivity, slight changes in color perception)

The above side effects are generally mild to moderate and subside over time. [Serious Side Effects (Rare but require vigilance)]

Sudden hearing loss

Vision loss (NAION)

Cardiac arrhythmia, myocardial infarction

Severe hypotension (especially when used with nitrates)

Allergic reactions (rash, itching, difficulty breathing)

[Drug Interactions]

Absolute contraindications: Nitrates, guanylate cyclase stimulators (e.g., riociguat)

Use with caution/dosage adjustment required:

Alpha-blockers (e.g., terazosin) → Increased risk of hypotension

Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir) → Increased plasma concentration of tadalafil

Antihypertensives → Potential potentiation of blood pressure-lowering effects

[Use in Special Populations]

Elderly (≥65 years): No routine dose reduction required, but monitor for side effects.

Hepatic impairment: Max dose 10 mg/day for moderate impairment; contraindicated in severe impairment.

Renal impairment: Max dose 10 mg every other day for severe impairment (CrCl <30 mL/min).

Pregnant/lactating women: Not applicable (for use by men only).

[Pharmacological Action]

Tadalafil is a selective phosphodiesterase-5 (PDE5) inhibitor. It enhances the nitric oxide (NO)-cGMP pathway, relaxes the smooth muscle of the corpus cavernosum, and increases blood flow, thereby facilitating an erection in response to sexual stimulation.

[Pharmacokinetics]

Absorption: Rapidly absorbed after oral administration; Tmax is approximately 2 hours.

Half-life: Approximately 17.5 hours (resulting in a prolonged duration of action).

Metabolism: Primarily metabolized by the hepatic enzyme CYP3A4.

Excretion: Feces (61%), urine (36%).

[Storage Conditions]

Store in a sealed container, protected from light, in a dry place below 25°C.

Keep out of reach of children.

[Packaging]

Aluminum-plastic composite sachet; approximately 10g per sachet; individually packaged.

[Important Information for Purchasing Sexual Health Products]

Note: Oral erectile aids for men require sexual stimulation to be effective; they do not automatically induce an erection. When using medications such as sildenafil, vardenafil, tadalafil, avanafil, or Priligy (dapoxetine), many people are concerned about whether the expected results will be achieved.

Based on clinical data and real-world feedback, there are slight variations in the proportion of users for whom these drugs prove ineffective:

Sildenafil: Approximately 15%–20% of users do not achieve the expected results;

Vardenafil: The rate of ineffectiveness is similar to that of sildenafil, at approximately 15%–22%;

Tadalafil: Due to its longer half-life and slightly broader suitability, the ineffectiveness rate is somewhat lower, at approximately 12%–18%;

Avanafil: Known for rapid onset and metabolism, the ineffectiveness rate is approximately 14%–19%;

Priligy: Targeted at premature ejaculation, its efficacy is heavily influenced by individual neurological sensitivity and psychological state; consequently, the ineffectiveness rate is relatively higher, at approximately 20%–25%.

It is important to clarify that suboptimal results in some users are not due to product quality issues, but rather the interplay between the drug's mechanism of action and the individual's physiological and pathological conditions. Even with original brand-name products, a significant percentage of users may not experience the desired effect; for instance, approximately 20% of men who use Pfizer’s Viagra (sildenafil) do not see results—this is not a quality defect. It is common for the same box of medication to work for one person but not another, or for a different product to work for the other person while failing to work for you. Our store guarantees that all sexual health products are 100% authentic, but we cannot guarantee that every user will achieve the expected results. Please consider this carefully before placing an order. Specific reasons vary by medication:

Sildenafil / Vardenafil / Avanafil: All three work by promoting vasodilation. Their effectiveness is influenced by individual metabolic capacity (liver and kidney function affecting the rate of drug breakdown), underlying medical conditions (e.g., diabetes or hypertension damaging blood vessels and reducing drug efficiency), and usage context (alcohol consumption inhibits efficacy; high-fat meals may delay the absorption of Sildenafil and Vardenafil). In cases of severe arterial disease, the drugs struggle to facilitate blood flow, naturally limiting their effectiveness.

Tadalafil: Although its mechanism is similar to the three mentioned above, it remains in the body longer. However, effectiveness is still influenced by individual drug sensitivity and factors such as severe prostate disease or spinal cord injuries; some individuals may experience suboptimal results due to weaker receptor binding affinity.

Priligy (Dapoxetine): Works by inhibiting neurotransmitter reuptake to improve ejaculation control. Effectiveness is closely linked to individual nerve conduction efficiency, psychological state (anxiety and tension can counteract the drug's effects), and whether the dosage matches body weight and the severity of the condition. If there is abnormal nerve sensitivity or long-standing psychogenic premature ejaculation, the drug's regulatory effect may be limited.

If the results from using any of the aforementioned drugs or dual-effect tablets fall short of expectations, avoid self-adjusting the dosage, switching medications, or continuing long-term use without guidance. Instead, consult a urologist or andrologist promptly. A doctor will assess your physical condition through a detailed consultation and, based on test results, adjust your treatment plan (e.g., optimizing dosage or changing medication type) or incorporate psychological interventions and behavioral training to create a solution better suited to your needs.

Specifications

Product Name: Apcalis Oral Jelly (7 sachets/box) 20mg

Common Name: Tadalafil Oral Jelly

Ingredients: Each sachet contains 20mg of Tadalafil

Dosage Form: Oral Jelly

Specifications: 7 sachets per box

Manufacturer: Ajanta Pharma Ltd

Indications: Treatment of male erectile dysfunction (ED/impotence)

Usage and Dosage: Recommended dose: Take 1 sachet (20mg) as needed, approximately 30 minutes to 1 hour before sexual activity. Maximum dosage: Once daily; do not exceed 20 mg per day.

Administration: Squeeze directly into the mouth and swallow; no water is required. May be taken on an empty stomach or with food (a high-fat meal may slightly delay the onset of action).

Onset of action: Typically takes effect within 30–60 minutes.