Product Name: Cenforce 100

English Name: Sildenafil Citrate Tablets

Active Ingredient:

Each tablet contains sildenafil citrate equivalent to 100mg sildenafil.

Package Size:

100 tablets per box

Appearance:

Blue film-coated tablets. After removing the coating, the tablet core appears white.

Indications / Therapeutic Use

Cenforce 100 (Sildenafil Citrate Tablets) is used for the treatment of erectile dysfunction (ED).

Dosage & Administration

For most patients, the recommended starting dose is 50mg, taken approximately 1 hour before sexual activity.

However, it may be taken anytime between 30 minutes and 4 hours before sexual activity.

Based on effectiveness and tolerance:

• The dose may be increased to 100mg (maximum recommended dose).

• The dose may be reduced to 25mg if needed.

Maximum frequency: Once daily.

Possible Side Effects

Common adverse reactions include:

• Headache

• Facial flushing

• Indigestion

• Nasal congestion

• Visual disturbances

Visual disturbances are usually mild and temporary, which may include:

• Changes in color perception

• Increased sensitivity to light

• Blurred vision

Contraindications

Cenforce 100 should not be used by:

• Patients taking any form of nitrate medication, whether taken regularly or intermittently

• Patients allergic to sildenafil or any ingredient contained in the product

Pharmacology & Mechanism of Action

Sildenafil citrate is an oral medication used for the treatment of erectile dysfunction.

It is a selective inhibitor of phosphodiesterase type 5 (PDE5), an enzyme involved in the regulation of blood flow in penile tissue.

Mechanism of action:

During sexual stimulation, nitric oxide (NO) is released in the corpus cavernosum of the penis.

NO activates guanylate cyclase, increasing levels of cyclic guanosine monophosphate (cGMP), which causes smooth muscle relaxation and increased blood flow into the penile tissue, resulting in an erection.

Sildenafil works by inhibiting PDE5, helping maintain higher levels of cGMP and supporting erection during sexual stimulation.

Drug Interactions

Effects of Other Drugs on Sildenafil:

In vitro studies show that sildenafil is mainly metabolized through:

• Cytochrome P450 3A4 (primary pathway)

• Cytochrome P450 2C9 (secondary pathway)

Medications that affect these enzymes may influence sildenafil concentration and effectiveness.

Pharmacokinetics

• Sildenafil is rapidly absorbed after oral administration.

• Peak blood concentration occurs approximately 30–120 minutes after administration.

• Effects may begin within approximately 1 hour.

• Bioavailability is approximately 40%.

Food may significantly reduce the speed and extent of absorption and delay the onset of action.

Sildenafil is mainly metabolized in the liver through CYP3A4 into active metabolites.

Elimination:

• Approximately 80% is excreted through feces.

• Approximately 13% is excreted through urine.

• Less than 0.001% is eliminated through semen.

Half-life:

• Sildenafil and its active metabolite: approximately 4 hours

Clearance may be reduced in:

• Men over 65 years old

• Patients with liver impairment

• Patients with severe kidney impairment

Precautions

The interaction between sildenafil and nitrate medications can significantly lower blood pressure.

Therefore, combining sildenafil with:

• Organic nitrates

• Nitric oxide donors (such as sodium nitroprusside)

is strictly contraindicated.

Use sildenafil with caution in patients with:

• Anatomical deformation of the penis (such as penile curvature, fibrosis of the corpus cavernosum, Peyronie's disease)

• Conditions that may increase the risk of prolonged erections, including:

• Sickle cell anemia

• Multiple myeloma

• Leukemia

The safety and effectiveness of combining sildenafil with other erectile dysfunction treatments have not been established, and combined use is not recommended.

Patients with existing cardiovascular risk factors should be aware that sexual activity itself may increase the risk of cardiac events.

If symptoms such as:

• Chest pain

• Dizziness

• Nausea

occur during sexual activity, stop immediately and seek medical attention.

Rare reports of:

• Prolonged erections lasting more than 4 hours

• Painful erections lasting more than 6 hours (priapism)

have been reported.

If an erection lasts longer than 4 hours, seek medical help immediately. Delayed treatment may cause permanent damage to penile tissue and possible permanent loss of erectile function.

Sildenafil does not protect against sexually transmitted diseases.

Use During Pregnancy & Breastfeeding

Sildenafil is not intended for use by:

• Women

• Pregnant women

• Breastfeeding women

• Newborns or children

Use in Elderly Patients

Healthy elderly volunteers aged 65 years or older may have reduced sildenafil clearance, resulting in higher blood concentrations.

Because higher concentrations may increase both effectiveness and adverse reactions, a lower starting dose of 25mg is recommended.

Storage Conditions

Store in a cool, dry place below 20°C.

Keep out of reach of children.

Important Information Before Purchasing Sexual Health Products

Note: Oral erectile dysfunction medications require sexual stimulation to work and will not automatically cause an erection.

When using medications containing sildenafil, vardenafil, tadalafil, avanafil, or dapoxetine, individual responses may vary.

Some users may not achieve the expected effect due to differences in:

• Physical condition

• Metabolism

• Underlying diseases

• Psychological factors

• Medication sensitivity

Possible reasons include:

Sildenafil / Vardenafil / Avanafil

These medications work by improving blood vessel relaxation and blood circulation.

Effectiveness may be influenced by:

• Liver and kidney metabolism

• Diabetes, hypertension, and vascular conditions

• Alcohol consumption

• High-fat meals affecting absorption

Patients with severe vascular disease may experience reduced effectiveness.

Tadalafil

Although tadalafil works through a similar mechanism, it has a longer duration of action.

Its effect may still vary depending on:

• Individual sensitivity

• Existing medical conditions

• Overall health status

Dapoxetine

Dapoxetine affects serotonin pathways involved in ejaculation control.

Its effectiveness may be influenced by:

• Nervous system sensitivity

• Psychological factors such as anxiety or stress

• Dosage suitability

• Severity of premature ejaculation

If the desired effect is not achieved after using any medication or combination product:

• Do not increase the dosage yourself.

• Do not switch medications without medical advice.

• Do not use long-term without professional guidance.

Consult a urologist or qualified healthcare provider for evaluation and personalized treatment recommendations.

Product Specifications

Product Name: Cenforce 100

Generic Name: Sildenafil Citrate Tablets IP 100mg

Active Ingredient:
Each tablet contains sildenafil citrate equivalent to 100mg sildenafil.

Dosage Form:
Blue film-coated tablet (white core after removing coating)

Package Size:
100 tablets per box

Manufacturer:
Centurion Laboratories

Indication:
For the treatment of erectile dysfunction (ED)

Dosage:
Recommended starting dose: 50mg approximately 1 hour before sexual activity.

May be taken 30 minutes to 4 hours before sexual activity.

Dose may be adjusted to:

• 100mg maximum recommended dose

• 25mg depending on tolerance

Maximum frequency: Once daily.