Zoladex LA 10.8mg

Generic Name: Goserelin Acetate Sustained-Release Implant

Brand Name: Zoladex

English Name: Goserelin Acetate Sustained-Release Implant

Manufacturer: AstraZeneca

Composition

Active Ingredient: Goserelin acetate

Specification: 10.8 mg/implant

Description

This product is a white to off-white cylindrical sustained-release implant, pre-loaded in a disposable syringe.

【Indications】

Prostate Cancer: For the palliative treatment of advanced prostate cancer.

Breast Cancer: For the treatment of hormone receptor-positive breast cancer in pre- and perimenopausal women.

Endometriosis: For symptom relief and reduction of endometriotic lesions.

Uterine Fibroids: For preoperative reduction of fibroid volume or alleviation of associated symptoms.

Precocious Puberty: Sometimes used to treat central precocious puberty in children.

【Dosage and Administration】

Recommended Dosage: 10.8 mg administered via subcutaneous injection every 12 weeks.

Injection Site: Subcutaneous injection into the anterior abdominal wall, alternating between the left and right sides.

Administration Method: To be administered by a qualified healthcare professional to ensure correct implantation.

【Adverse Reactions】

Common adverse reactions include:

Male patients: Hot flashes, decreased libido, erectile dysfunction, injection site reactions.

Female patients: Hot flashes, hyperhidrosis (excessive sweating), decreased libido, vaginal dryness, mood swings.

Others: Headache, decreased bone mineral density (with long-term use), abnormal liver function.

【Contraindications】

Contraindicated in patients allergic to goserelin or any component of the product.

Contraindicated in pregnant women.

Use with caution in breastfeeding women.

【Precautions】

Effect on Bone Mineral Density: Long-term use may lead to a decrease in bone mineral density; regular monitoring is recommended.

Diabetes Risk: May affect blood glucose control; diabetic patients require close blood glucose monitoring.

Cardiovascular Risk: May increase the risk of cardiovascular events; use with caution in high-risk patients.

Injection Site Reactions: Local pain, redness, or swelling may occur after injection; these usually resolve spontaneously. [Drug Interactions]

Hormonal drugs: Avoid concomitant use with other hormonal drugs.

Anticoagulants: May increase the risk of bleeding; close monitoring is required.

[Pharmacological Action]

Goserelin is a gonadotropin-releasing hormone (GnRH) analogue. It exerts its therapeutic effect by continuously inhibiting the secretion of pituitary gonadotropins, thereby lowering sex hormone levels.

[Storage]

Store below 25°C; do not freeze.

Keep out of reach of children.

[Packaging]

1 unit per box, pre-filled in a disposable syringe.

[Shelf Life]

36 months.

[Important Note]

This product is a prescription drug and must be used under the guidance of a physician.

Please read the package insert carefully before use; consult a physician or pharmacist if you have any questions.

Do not use this product for indications not mentioned in the package insert.

Specifications

Product Name: Zoladex LA 10.8 mg (Goserelin Acetate Sustained-Release Implant)

Common Name: Zoladex

Active Ingredient: Goserelin acetate

Dosage Form: White to off-white cylindrical sustained-release implant, pre-filled in a disposable syringe.

Specification: 10.8 mg/unit

Manufacturer: AstraZeneca

Indications:

Prostate cancer: Palliative treatment of advanced prostate cancer.

Breast cancer: Treatment of hormone receptor-positive breast cancer in premenopausal and perimenopausal women.

Endometriosis: Symptom relief and reduction of endometriotic lesions.

Uterine fibroids: Preoperative reduction of fibroid size or alleviation of associated symptoms.

Precocious puberty: Sometimes used to treat central precocious puberty in children.

Dosage and Administration:

Recommended dose: 10.8 mg administered via subcutaneous injection every 12 weeks.

Injection site: Subcutaneous injection into the anterior abdominal wall, alternating between the left and right sides.

Administration method: To be administered by a qualified healthcare professional to ensure correct implantation.